Rsearch status of tenofovir on renal toxicity and pharmacogenetics

VernacularTitle:替诺福韦的肾毒性及其遗传药理学研究状况
Author: Wan-Ying YU ¹ ; Jie HUANG ; Guo-Ping YANG
Author Information

1. 中南大学药学院
Keywords: tenofovir; nephrotoxicity; genetic factors
From: The Chinese Journal of Clinical Pharmacology 2015;(14):1459-1461,1465
CountryChina
Language:Chinese
Abstract: Tenofovir ( TFV) is a class of inhibiting HIV-1 reverse tran-scriptase , adenosine phosphate acyclic nucleoside analogs.Because of its high effectiveness, low toxicity and only be taken once per day, it is widely used nowadays.However, it was reported that the drug can cause kidney damage.Since there is a high individual difference of renal im-pairment, more and more researches focus on the association of renal in-jury which caused by TFV and genetic factors. The nephrotoxicity of tenofovir and the genetic factors which may increase renal tubular disease are reviewed in this paper.