Study of acute toxicity of Meng gen wu sen ri le in mice

VernacularTitle:孟根乌森乌日乐对小鼠的急性毒性研究
Author: Yu QING ¹ ; Batudeligen ; Zhi-Qiang HAN ; Na TA
Author Information

1. 蒙古民族大学附属医院蒙药药理研究所
Keywords: mongolian medicine; Meng gen wu sen ri le; mice; acute toxicity
From: The Chinese Journal of Clinical Pharmacology 2015;(14):1446-1448
CountryChina
Language:Chinese
Abstract: Objective To investigate the study of acute toxicity of mon-golian medicine Meng gen wu sen ri le, to understand the dose of acute toxicity and distribution and death of acute toxicity after the administra-tion, to determine lethal dose 50 ( LD50 ) of Meng gen wu sen ri le. Methods According to the results of preliminary experiments, using Conn synthesis method ( modified Karber method ) , divided into six groups dosage are 14.30, 9.28, 6.04, 3.92, 2.55, 1.66 g? kg-1 , af-ter experiments observing 14 day, to record the change of the weight and adverse reaction.Results LD50 of Meng gen wu sen ri le is 5.1597 g? kg-1 ( 95%CI:3.6652-7.2637 g? kg -1 ).In 14 days, it does not appear obvious symptoms of adverse reaction and body weight has growth trends.Conclusion According to the results of experiments, LD50 of Meng gen wu sen ri le is 100 times of the clinical dosage, tip single oral is safer.