Protective effect of Rhubarb flavonoids on rats with diabetic nephropathy
10.13699/j.cnki.1001-6821.2015.14.025
- VernacularTitle:大黄黄酮对糖尿病肾病大鼠的改善作用
- Author:
Jian-Bo WANG
1
;
Yu-Xing PAN
;
Zhen-Tian CHENG
Author Information
1. 潍坊市益都中心医院 药学部
- Keywords:
Rhubarb flavonoids;
diabetic nephropathy;
protective effect on renal;
mechanism
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1439-1442
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the renal protective mechanism of Rhubarb flavonoids in diabetic rats. Methods Sixty SD rats were assigned into six groups: blank group, model group, control group ( Huangkui capsule, 675 mg? kg-1 ) , high, middle, low doses of test groups(Rhubarb flavonoids, 42,21,10 mg? kg -1).The microalbumin-uria, serum glucose, blood urea nitrogen, creatinine, total cholesterol and triglyceride levels were determined at the time of 90 days after administration.And renal tissues was observed by light microscopy. Results Compared with the model group, the rats in high, middle test groups ( 42, 21 mg? kg-1 ) significantly reduced the blood glucose, blood urea nitrogen, serum creatinine, urinary albumin and improve glomerular pathological structure of rat, whereas the low dose group were not significantly changed.Conclusions Rhubarb flavonoids has signifi-cant effects on rats with diabetic nephropathy for renal protective.
