Influence of combination of narrow band ultraviolet B and tacrolimus ointment on skin melanin expression in models with vitiligo
10.13699/j.cnki.1001-6821.2015.14.022
- VernacularTitle:窄谱中波紫外线联合他克莫司对白癜风模型表皮中黑色素表达的影响
- Author:
Ya-Ning JIAO
1
;
Min JIANG
;
Jun-Hui LI
;
Xiao-Shuai LIU
;
Zhen-Dong ZHONG
;
Li XIA
;
Li LIANG
;
Jing-Xia WANG
Author Information
1. 宁夏医科大学 总医院
- Keywords:
vitiligo;
tacrolimus ointment;
narrow band ultraviolet B;
melanin
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1429-1431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in the number of skin melanin after combined treatment of narrow band ultraviolet B ( NB-UVB) and tacrolimus ointment in animal models with vitiligo. Methods Animal models with vitiligo were built first.And then all the animal models were randomly divided into six groups of eight according to the principle of weight balance:normal group,model group,control group ( where vaseline was used in the shed white spot areas in the back of animal model, these two methods were implemented 2 times per day ), medication alone group(0.03%tacrolimus ointment skin smear,these two methods were implemented 2 times per day), light alone group(white spot area use NB-UVB irradiation, these two methods were irradiation once every other day ) , combination group ( topical tacrolimus combination NB-UVB irradiation,frequency,method and time same to medication a-lone group and light alone group).The differences of the number of mela-nin in the skin tissue before and after medication were checked and com-pared and irradiation by histopathology.Results The effect of the com-bined group on skin melanin express was significantly different compared with model group ( P<0.01 ) .Conclusion Combination of NB -UVB and tacrolimus ointment has a significant effect on vitiligo treatment.
