Effect of snail polypeptide on skin healing and expression of basic fibroblast growth factor mRNA in rats with scalded wound
10.13699/j.cnki.1001-6821.2015.14.021
- VernacularTitle:蜗牛多肽对大鼠皮肤烫伤创面的愈合及碱性成纤维生长因子 mRNA表达的影响
- Author:
Peng-Tao CAO
1
;
Shi-Peng LI
;
Lu-Lu ZHANG
;
Pei-Zhe ZHANG
;
Xiao-Han YUAN
;
Jun-Ling AN
;
Shou-Min XI
Author Information
1. 河南科技大学 医学院
- Keywords:
snail polypeptide;
scalded wound;
skin healing;
basic fibroblast growth factor
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1426-1428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of snail polypeptide on skin healing and expression of basic fibroblast growth factor ( bFGF) mRNA in rats with scalded wound.Methods The deepⅡscald model was estab-lished in 60 rats by using 90 ℃ hot water.And the rats were randomly divided into model group and the test group.Rat burn sites in test group were smeared with SP solution(10 mg? mL-1 ).Skin healing rate,skin healing time and the scab off time were observed in each group of rats. The mRNA expression of skin tissue bFGF was detected by RT-PCR. Results Healing rate of test group at different times after treatment were significantly higher than the model group, with statistically significant difference ( P <0.05 or P <0.01 ) .Compared with the model group, burn the skin healing time scab off times are significantly shorter in test group, the difference was statistically significant ( P <0.05 ) .Mean-while, SP increased the expression of bFGF mRNA at different times. Conclusion SP can promote wound healing in rat skin burns, and its mechanism may be related to regulating bFGF mRNA expression.