Vascular endothelial growth factor and sflt -1 expression in patients with recurrence spontaneous abortion
10.13699/j.cnki.1001-6821.2015.14.014
- VernacularTitle:血管内皮生长因子及其可溶性受体表达水平与复发性自然流产相关性研究
- Author:
Yi-Hong CHEN
1
;
Ji-Fen HU
Author Information
1. 福建医科大学 附属第一医院 妇产科
- Keywords:
vascular endothelial growth factor;
soluble vascular endothe-lial growth factor receptor-1;
recurrence spontaneous abortion
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1402-1404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of vascular endothelial growth factor ( VEGF ) and soluble vascular endothelial growth factor receptor-1(sflt-1) expression in patients with recurrence spontaneous abortion ( RSA ) . Methods Thirty -eight patients with RSA were included as experiment group.And 40 subjects of artificial abortion at the same period were recruited as the control group.The VEGF and sflt-1 expression level were arrayed in the serum and chorionic villi in the two groups by enzyme-linked immunosorbent assay and immunohistochemis-try assay. Results The serum level of VEGF and sflt -1 were (2248.8 ±1456.8),(11656.8 ±2421.6)ng? L-1 in experiment group, much higher than ( 945.8 ±601.2 ) , ( 3012.5 ±1891.2 ) ng? L-1 in control group with statistical difference ( P<0.05 ) .The positive rate of VEGF were ( 73.7% vs 45.0%) and sflt -1 ( 94.7% vs 70.0%) in experiment group and control group, which in experiment group was much higher than that in control group ( P<0.05 ) .Conclusion The abnormal expression of VEGF and sflt -1 may be associated with the occurrence of RSA.
