Effect of compound tropicamide eye drop on measurement of central corneal thickness
10.13699/j.cnki.1001-6821.2015.14.012
- VernacularTitle:复方托吡卡胺对中央角膜厚度测量的影响
- Author:
Yuan ZENG
1
;
Yi LI
Author Information
1. 成都军区昆明总医院
- Keywords:
compound tropicamide eye drop;
central corneal thickness;
corneal laser refractive surgery
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1396-1398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of compound tropicamide eye drops on the measurement of central corneal thickness and to investi-gate the duration of the effect.Methods In this trial, 240 eyes of 120 myopic patients undergoing corneal laser refractive surgery were selected, and central corneal thicknesses were measured before treatment and 1 , 4 h after administration of compound tropicamide eye drops using OrbscanⅡ anterior segment analysis system and SP -2000P non -contact specular microscope, respectively.Results The central corneal thick-ness was (545 ±27),(559 ±31) and (544 ±26) μm before and 1 and 4 h after administration, measured with Orbscan Ⅱ anterior segment analysis system, whereas being ( 508 ± 26 ) , ( 521 ±29 ) and (506 ±24) μm measured with SP -2000P non -contact specular microscope.The central corneal thickness measured with both OrbscanⅡsystem and SP-2000 P microscope increased 1 h after administration of compound tropicamide eye drops as compared to that before administra-tion ( P <0.01) , and the central corneal thickness measured with both Orbscan Ⅱ system and SP -2000P microscope decreased 4 h after administration of compound tropicamide eye drops as compared to that 1 h after administration ( P <0.01 ) , while no significant difference was observed in central corneal thickness measured with either Orbscan Ⅱ system or SP -2000 P microscope between 4 h after administration of Mydrin eye drops and before application. Conclusion Central corneal thickness increases 1 h after the application of compound tropicamide eye drops, and the effect of compound tropicamide eye drops on central corneal thickness is eliminated at 4 h following administration. During the examination prior to excimer laser corneal refractive surgery, measurement of central corneal thickness should be performed before or 4 h after administration of compound tropicamide eye drops.
