Effect of ligustrazine in the treatment of non proliferative diabetic retinopathy and on serum hypoxia-inducible factor-1, vascular endothelial growth factor
10.13699/j.cnki.1001-6821.2015.14.011
- VernacularTitle:川芎嗪治疗非增殖期糖尿病视网膜病变的临床疗效及其对血清 HIF－1、VEGF的影响
- Author:
Yi WANG
1
;
Jie-Hui XU
;
Ren LI
Author Information
1. 浙江医院眼科
- Keywords:
ligustrazine;
nonproliferative diabetic retinopathy;
curative effect;
hypoxia-inducible factor-1;
vascular endothelial growth factor
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1393-1395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the curative effect of ligustrazine in the treatment of non proliferative diabetic retinopathy ( NPDR) and its affect on hypoxia-inducible factor-1 ( HIF-1 ) , vascular endothelial growth factor ( VEGF) in serum.Methods Select the NPDR total of 60 patients ( 120 eyes ) were randomly divided into two groups. Control group(30 cases, 60 eyes) were given regulate blood sugar, diet control, exercise therapy and other conventional treatment.Based on therapy of Control group, Treatment group (30 cases, 60 eyes) were treated with Li-gustrazine 0.24 g+0.9%NaCl 250 mL intravenous infusion qd.Treat-ment for 2 weeks.The expression of serum HIF-1, VEGF and clinical curative effect of two groups were compared.Results Total effective rate of Treatment group (96.67%) was significantly better than Control group (83.33%), there were significant differences (P<0.05).The expres-sion of HIF -1, VEGF in Treatment group ( 25.26 ±10.14 ), (88.36 ±16.54) was lower than in Control group (37.59 ±10.26), (102.40 ±21.35)significantly, the difference was statistically significant ( P<0.05 ) .There were not significant adverse reactions in two groups during treatment.Conclusion Ligustrazine has a better curative effect on NPDR, and its mechanism may be associated with the downregulation of expression of HIF-1, VEGF.
