Nearly and long -term clinical effect of exenatide in obese adolescents with abnormal glucose metabolism
10.13699/j.cnki.1001-6821.2015.14.010
- VernacularTitle:艾塞那肽在糖调节受损的青少年肥胖患者中的近、远期效果的临床研究
- Author:
Zhao-Sui HUANG
1
;
Zhao-Xuan HUANG
;
YANG-jiao
;
Li-Li LUAN
;
Ci-Yu WANG
;
Hong-Ying YANG
Author Information
1. 厦门大学 附属成功医院 内分泌科
- Keywords:
exenatide;
abnormal glucose metabolism;
adolescent;
obesity
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1390-1392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the nearly and long-term effect of exenatide in obese adolescents with abnormal glucose metabolism. Methods A total of 92 cases of obese adolescents with abnormal glucose metabolism were randomly divided into two groups.Patients in the control group (45 cases) were treated with metformin 0.5 g tid.And those in the trial group (47 cases) were treated with metformin 0.5 g tid com-bined with exenatide ih for 6 months.The data of body weight, waist circumference, body mass index ( BMI) , fasting plasma glucose ( FPG) , 2-hour postprandial blood glucose ( 2 h PG ) , glycated hemoglobin ( HbA1 c ) , systolic blood pressure ( SBP ) , diastolic blood pressure ( DBP) , triglyceride ( TG) , total cholesterol ( TC) , high density lipopro-tein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and fasting insulin (FINS), insulin resistance (HOMA-IR), as well as pancreatic β-cell function index ( HOMA-β) were determined before and after the treatment between two groups. The incidence rate of diabetes and hypertension were observed after three years in long-term study.Results There were significant decreases in the body weight,waist circumference and BMI in trial group ( P<0.01 ) .Compared with those in control group and themselves before treatment, there were significant decreases in 2h PG、HbA1c ( P <0.05 ) .The data of TC, LDL -C, TG were decreased in trial group (P<0.05).The SBP was significantly decreased in trial group, compared with those in con-trol group, there was statistical significant difference (P<0.05).The FINS, ISI, HOMA-IR were decreased in trial group while the HOMA-βwas increased ( P<0.01 ) , compared with those in control group and themselves before treatment, the difference was statistically significant ( P <0.05 ) .Conclusion Exenatide can significantly reduce body weight, improve endocrine metabolism and reduce the incidence of metabolic abnormalities disease caused by obesity.
