Clinical efficacy and safety of amisulpride in treatment of patients with mental disorders due to alcohol
10.13699/j.cnki.1001-6821.2015.14.006
- VernacularTitle:氨磺必利治疗乙醇所致精神障碍的临床疗效及安全性评价
- Author:
Li XU
1
;
Lian-Zhou CHEN
;
De-Zhi ZENG
;
Xue-Gang DONG
Author Information
1. 宁波市精神病院精神科
- Keywords:
mental disorders due to use of alcohol;
amisulpride;
efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1379-1381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of domestic amisulpride in treatment of patients with mental disorders due to alcohol.Methods One hundred twenty patients with mental disorders due to use of alcohol were choosed and randomly assigned to treatment group and control group, each group was 60 cases.Treatment group was treated with amisulpride 100 mg? d -1 for the starting dose.Control group was treated with perphenazine 4 mg? d-1 for the starting dose.Two groups were adjusted to the appropriate dose in two weeks, and observed for 8 weeks.To compare the clinical efficacy and adverse drug reactions by positive and negative syndrome scale ( PANSS ) and treatment emergent symptom scale (TESS).Results The clinical efficacy in the treatment group was significantly better than that in control group in the 2nd, 4th and 8th weekend after treatment(P<0.05).The scores of the PANSS in the both groups after treatment were significantly lower than before (P<0.01).Except the positive factor of PANSS, the decrease ranges of the scores in treatment group was significantly greater than those in the control group ( P<0.05 or P<0.01 ) .The incidence of adverse drug reactions and the rate of drug combination in the treatment group was significantly lower than those in the control group ( P<0.01). Conclusion Domestic amisulpride is rather effective and safe in
treatment of patients with mental disorders due to use of alcohol.Therefore, it can be the preferred antipsychotic drugs.
