Effect of alfacalcidol soft capsules on immune function in patients with chronic obstructive pulmonary disease
10.13699/j.cnki.1001-6821.2015.14.004
- VernacularTitle:阿法骨化醇软胶囊对慢性阻塞性肺疾病患者免疫功能的临床研究
- Author:
Hai-Ting GU
1
;
Hai-Yan SHAO
;
Xiao-Hong JIN
;
Wen-Wei MAO
Author Information
1. 温岭市第一人民医院 呼吸内科
- Keywords:
alfacalcidol soft capsule;
immune function;
chronic obstructive pulmonary disease;
pulmonary function
- From:
The Chinese Journal of Clinical Pharmacology
2015;(14):1373-1375
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of alfacalcidol soft capsules on immune function in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 172 COPD patients were random-ly divided into the trial group ( n=86 ) and the control group ( n=86 ) . They all accepted the conventional treatment, but the patients in the trial group were given the treatment of alfacalcidol soft capsules 0.25μg? d -1 for 6 months.The difference of immune function ( CD3 +, CD4 +, CD8 +and CD4 +/CD8 +), pulmonary function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, diffusion capacity for carbon monoxide of lung/alveolar volume ( DLCO/VA ) ] and acute exacerbations of COPD during 6 months follow -up were compared between the two groups.Results The contrations of CD3 +, CD4 +, CD8 +and CD4 +/CD8 +after treatment in the trial group were significantly higher than that before treatment and control group (P<0.05).The FEV1,FEV1/FVC,DLCO/VA after treatment in the trial group were significantly higher than that before treatment and control group(P<0.05).There were no significant difference of CD3 +,CD4 +, CD8 +, CD4 +/CD8 +, FEV1, FEV1/FVC, DLCO/VA before and after treatment in the control goup(P>0.05).The rate of acute exacerbations of COPD in the trial group (9.30%)was sig-nificantly lower than that in the control group ( 25.58%) during 6 months follow-up.Conclusion Alfacalcidol soft capsules could improve the pulmonary function and reduce acute exacerbations by improving immune function of patients with COPD.
