Systemic review and Meta-analysis of therapeutic drug monitoring of vancomycin in intensive care unit patients
10.13699/j.cnki.1001-6821.2015.13.042
- VernacularTitle:重症监护病房患者万古霉素治疗药物监测的系统评价
- Author:
Qian-Ru DONG
1
;
Xi-Lan ZHAO
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
vancomycin;
therapeutic drug monitoring;
intensive care unit;
systematic review
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1358-1360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematic evaluate the necessity of vancomy-cin therapeutic drug monitoring in intensive care unit ( ICU ) patients compare with general ward patients . Methods Electronic databases such as PubMed , Embase , the Cochrane library and Chinese database (CNKI, WanFang, CBM) were searched from establishment dates of databases to January 2014.The clinical observational studies which in-clude ICU patients using vancomycin intravenously was identified .The studies were screened according to the inclusion and exclusion criteria , the data were extracted , the quality of the included studies was assessed , and Meta-analysis was performed using Rev Man 5.3 software. Results Three cohort studies were identified . One study shows no difference in the rate of treatment failure of ICU compare with general ward patients ( P>0.05 ) .Two studies shows nephrotoxicity increased significantly of ICU patients compare with general ward patients (P<0.05).Conclusion As the increase of nephrotoxicity and large individual difference , ICU patients need vancomycin TDM more .Due to the low methodological quality of the included studies , more high -quality clinical studies need to be conducted to verify this conclusion .
