Relationship between individualized vancomycin regimens and clinical outcomes:systematic review and Meta analysis
10.13699/j.cnki.1001-6821.2015.13.041
- VernacularTitle:万古霉素个体化给药方法与临床结局相关性的Meta分析
- Author:
Rui JIAO
1
;
Ran XIE
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
vancomycin;
individualized administration;
population pharmacokinetics;
therapeutic drug monitoring
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1353-1357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically assess the relationship between individualized vancomycin regimens and clinical outcomes .Methods Electronic databases such as PubMed , EMbase, CNKI were searched. The clinical studies which focus on individualized vancomycin regimens was identified.Meta-analysis was conducted by Revmen 5.3 software. Results A total of 6 studies were included ,involving 797 patients.The results of Meta -analysis revealed that compared with conventional group, there was a significant differences in attainment of target concen-tration and microbiological eradicated rates of patient -tailored group (P<0.05), but no significant differences in mortality , clinical cure rates and nephrotoxicity ( P>0.05 ) .There was a significant differences in attainment of target concentration between therapeutic drug monitoring ( TDM) and non -TDM groups ( P<0.05 ) .Conclusion A patient -tailored initial dosing regimens may increases the attainment of target con-centration and microbiological eradicated rates .Adjust dosing regimen with TDM may increases the attainment of target concentration .
