Systematic review and Meta-analysis of continuous versus intermittent infusion of vancomycin
10.13699/j.cnki.1001-6821.2015.13.040
- VernacularTitle:万古霉素持续输注与间断输注的系统评价与Meta分析
- Author:
Jing-Yi XUE
1
;
Xiao-Han XU
;
Ken CHEN
;
Hui-Lin TANG
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
vancomycin;
continuous infusion;
intermittent infusion;
systematic review;
Meta-analysis
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1348-1352
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To compare the effects of treating adults with gram-positive bacteria by using two different administration of vancomy-cin: continuous and intermittent infusion .Methods English database (PubMed, EMBase, Cochrane Library) and Chinese database (CNKI, WanFang, CBM, Chinese BioMedical Literature Database ) was searched systematically.Randomized controlled studies and observational studies that focused on the association between vancomycin continuous infusion and discontinuous infusion were included .Descriptive analysis and the Meta-analysis, taken by Rev Man 5.0 ,was conducted if studies were abled to be combined.Results Seven observational studies and 1 ran-domized controlled rrial were included in the systematic review , including 869 patients in all , 535 patients with continuous infusion , 334 patients with intermittent infusion . The results of Meta -analysis showed that there was no significant difference between continuous infusion group and intermittent infusion group in the incidence of clinical failure [ RR=0.83 , 95%CI ( 0.56 , 1.23 ) , P >0.05 ] and morality [ OR=1.56 , 95%CI ( 0.91 ,2.66 ) , P>0.05 ] .However , continuous infusion group was better than intermittent infusion group in the incidence of renal toxicity [ OR =0.61 , 95%CI ( 0.39 , 0.94 ) , P <0.05 ] . Conclusion Vancomycin continuous infusion is better than the intermit-tent infusion in renal toxicity incidence.There is no significant difference between the two groups in incidence of clinical failure and morality .
