Systemic review and Meta -analysis of therapeutic drug monitoring in cancer patients

VernacularTitle:肿瘤患者万古霉素治疗药物监测的系统评价和 Meta分析
Author: Qian-Ru DONG ¹ ; Xi-Lan ZHAO ; Suo-Di ZHAI
Author Information

1. 北京大学第三医院药剂科
Keywords: vancomycin; therapeutic drug monitoring; cancer; system-atic review
From: The Chinese Journal of Clinical Pharmacology 2015;(13):1344-1347
CountryChina
Language:Chinese
Abstract: Objective To systematic evaluate the necessity of vancomy-cin therapeutic drug monitoring in cancer patients .Methods Electronic databases such as PubMed , EMBase, Cochrane library and Chinese data-base (CNKI, WanFang, CBM) were searched from establishment dates of databases to January 2014.The clinical observational studies which in-clude cancer patients using vancomycin intravenously was identified .The studies were screened according to the inclusion and exclusion criteria , the data were extracted , the quality of the included studies was assessed , and Meta -analysis was performed using Rev Man 5.3 software. Results Six cohort studies were identified .Compared with no -cancer patients, infectious treatment failure increases significantly (P<0.05), the target concentration rate of vancomycin decrease significantly (P<0.05).Conclusion As the decrease of target concentration rate and increase of treatment failure , cancer patients need therapeutic drug monitoring ( TDM) to adjust the dose of vancomycin .