Correlation between amount of antibiotics and antimicrobial resistance of Acinetobacter baumannii in our hospital
10.13699/j.cnki.1001-6821.2015.13.029
- VernacularTitle:本院鲍曼不动杆菌的耐药率与常用抗菌药物用量的相关性分析
- Author:
Ning CHEN
1
;
Jin LI
;
Jian-Cun ZHEN
Author Information
1. 北京积水潭医院药剂科
- Keywords:
Acinetobacter baumannii;
drug resistance;
antibiotics;
defined daily dose;
correlation
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1312-1314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and antimicrobial resistance of clinical isolates of Acinetobacter baumannii isolated from our hospitalized patients from 2008 to 2013 , and analyze the correlation be-tween the medication frequency and the drug resistance .Methods The distribution and the drug susceptibility testing for Acinetobacter baumannii isolated from clinical specimens were retrospectively analyzed .The using trend of antibiotics was analyzed by calculation the DDDs .The relation-ship between the drug resistance rate and defined daily dose ( DDDs) was statistically analyzed.Results Acinetobacter baumannii varied in drug resistance,the drug resistance rates to penicillins ,cephalosporins,quino-lones,and carbapenems were high.In 2013,no antibacterial drugs is sen-sitive to Acinetobacter baumannii rate of more than 50%.The resistance rate of Acinetobacter baumannii was negatively correlated with the dosage of piperacillin/tazobactam.Conclusion The resistance rate of Acineto-bacter baumannii is high.And the isolates are multidrug resistant .
