Therapeutic drug monitoring for peripartum use of imipenem/cilastatin
10.13699/j.cnki.1001-6821.2015.13.025
- VernacularTitle:围生期孕产妇应用亚胺培南／西司他丁钠的治疗药物监测
- Author:
Wei LIU
1
;
Li-Qin ZHU
;
Xian-Hu ZHANG
;
Yuan WEI
;
Xin XIONG
;
Yang LIU
;
Li YANG
Author Information
1. 北京大学第三医院
- Keywords:
imipenem/cilastatin;
peripartum;
therapeutic drug monito-ring;
HPLC
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1302-1303,1306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report a case of peripartum use of imipenem/cilastatin supported by therapeutic drug monitoring ( TDM ) technique. Methods A 29-week pregnant woman was prescribed imipenem/cilas-tatin because of intrauterine infection , to ensure the safety of this Food and Drug Administration ( FDA ) Class C drug , pharmacists carried out TDM for this patient.Results and Conclusion By establishing a rapid analyzing method , the parent venous blood and fetus umbilical cord blood was measured.The concentration of imipenem/cilastatin were within nor-mal range in both the mother and the baby .Through follow-up, no ad-verse event were developed and both were discharged later .By providing TDM and pharmaceutical care , the pharmacists supported the clinical us-age of peripartum anti -infectious therapy , and more experience and con-fidence would be gained and shared .
