Study the concentration difference of voriconazole in mice serum and lung tissue by voriconazole atomization inhalation or intravenous injection
10.13699/j.cnki.1001-6821.2015.13.015
- VernacularTitle:伏立康唑雾化吸入和静脉注射在小鼠血清和肺组织中药物分布的差异性研究
- Author:
Jie TIAN
1
;
Gui-Ning ZHANG
;
Shao-Jie DENG
;
Jin-Ping WANG
;
Ding-Ping SHE
;
Jian-Long WU
Author Information
1. 深圳市第二人民医院 药学部 临床药学科
- Keywords:
voriconazol;
drug concentration;
atomization inhalation;
intravenous injection;
mice
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1268-1270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the drug concentration difference of voriconazole in mice serum and lung tissue by voriconazole atomization inhalation or intravenous injection , to supply the evidence for the vori-conazole atomization inhalation.Methods Mice were given voriconazole by atomization inhalation ( treatment group ) or intravenous injection ( con-trol group.The serum and lung tissue were collected before voriconazole administration and after 30 minutes on the forth day , seventh day and tenth day , then assay the voriconazole concentration of serum and lung tissue.The liver and renal index were also assayed .Results In the treatment group , the peak concentration and the trough concentration in lung tissue were higher than the serum concentration . In the control group, the peak concentration in serum was higher.Meanwhile, the trough concentration decreased evidently .The serum concentration was higher than the lung tissue concentration .The peak concentration in lung tissue was lower in treatment group than in the control group .But the trough concentration was higer in treatment group than in the control group after 7, 10 days administration.The mice in control group had an elavatin of serum alanine transaminase after 7 days administration.Conclusion The voriconazole concentration in ser-um was low and the drug concentration in mice lung tissue last longer by voriconazole atomization inhalation .Voricon-azole atomization inhalation had less influence on the liverfunction .
