Improving effects of mesylate cinepazide on neurological function of focal cerebral ischemia in rats
10.13699/j.cnki.1001-6821.2015.13.013
- VernacularTitle:注射用甲磺酸桂哌齐特对局灶性缺血脑梗死大鼠的神经改善作用
- Author:
Jian-Bo WANG
1
;
Yu-Xing PAN
;
Zhen-Tian CHENG
Author Information
1. 潍坊市益都中心医院 药学部
- Keywords:
mesylate cinepazideon;
focal cerebral ischemia infarction;
infarct size;
infarction rate
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1262-1264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of mesylate cinepazideon on focal cerebral ischemia infarction in rats .Methods Sprague -Daw-ley(SD) rats were randomly divided into six groups:sham group, model group, control group ( cinepazide maleate 29 mg? kg-1 ) , three doses test groups (mesylate cinepazideon,45,22.5,11.25 mg? kg -1).Twenty-four hours after administration , Zea -Longa method was used to assessment the neurological disfunction scores .Triphenyltetrazolium chlo-ride ( TTC) staining was used to measure cerebral infarction size .Histo-pathology were determined with hematoxylin - eosin staining. Results Compared with model group , the infarction area were signifi-cantly reduced in high , middle test groups ( 45 , 22.5 mg? kg -1 ) and control group.And neurologic function were improved in high , middle doses test groups.Conclusion Infarction area was reduced and neuro-logical function was improved on nerve cells after administration .
