Pharmcokinetics of moxifloxacin in Chinese healthy volunteers
10.13699/j.cnki.1001-6821.2015.13.011
- VernacularTitle:莫西沙星在中国健康受试者体内的药代动力学研究
- Author:
Yin-Ping LIU
1
;
Yun-Hua QIN
;
Nan BAI
;
Ming-Jing TANG
;
Rui WANG
;
Hong-Wei ZHAO
Author Information
1. 河南省人民医院药学部
- Keywords:
moxifloxacin;
high performance liquid chromatograraphy -tandem mass spectrometry;
pharmacokinetic
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1255-1257
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of oral administra-tion of moxifloxacin in Chinese healthy volunteers .Methods The study was designed as an open , randomized , parallel and single -dose cycle study.The volunteers were administered with a single dose of moxifloxa-cin 400 mg for consistent four days , respectively.The plasma concentra-tions of moxifloxacin were determined by LC -MS/MS method. The pharmacokinetic parameters of moxifloxacin were calculated by WinNon-lin 5.2.1 software.Results Six subjects quit from the study , and the main pharmacokinetic parameters of the remaining 42 subjects were as follows:t1/2 was (11.71 ±3.53 ) h, Cmax was (0.51 ±0.19 ) ×10 -4 ng? mL-1, tmax was(2.94 ±1.41) h, MRT0-24 hwas(18.02 ±4.45)h, CLz/F was ( 0.84 ± 0.75 ) × 10 -4 mL ? h-1 , AUC0-24 h was (5.82 ±1.82 ) ×10 -4 ng? mL-1? h.Conclusion The characteristics of oral moxifloxacin 400 mg has shown a high blood concentration , long half-life time and it can be well tolerated.The doses adopted in foreign study is recommended .There was a gender difference in volunteers when with same dose of moxifloxacin .
