Clinical efficacy of Kanggu Zengsheng capsule on treatment of knee-osteoarthritis
10.13699/j.cnki.1001-6821.2015.13.009
- VernacularTitle:抗骨增生胶囊治疗膝骨关节炎的临床研究
- Author:
Kai ZHOU
1
;
Lei CHEN
;
Jun-Zhe LANG
;
Jing LI
;
Cheng-Wei CHEN
;
Chao ZHANG
;
Kai CHEN
Author Information
1. 温州医科大学 附属第一医院 骨科
- Keywords:
Kanggu Zengsheng capsule;
knee-osteoarthritis;
inflammatory factor;
antioxidase
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1249-1251,1261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of Kanggu Zengsheng capsule on treatment of knee -osteoarthritis and its effect on anti -inflammation and anti -oxidation. Methods One hundred patients with knee-osteoarthritic were randomly divided into two groups . Patients in the treatment group ( n=50 ) were orally administrated with 3 Kanggu Zengsheng capsules each time , tid, and those in the control group (n=50) were given diacerein (50 mg bid, po) and celecoxib (200 mg qd, po) for four weeks.The data of Visual Analogue Scale ( VAS ) , Womac score , Lequesne index and interleukin 1 beta ( IL-1β) , tumor necrosis factor alpha ( TNF-α) , matrix metallopro-teinases-3 ( MMP-3 ) , hyaluronic acid ( HA ) , nitric oxide ( NO ) , nitric oxide synthase ( iNOS ) , lipid peroxide ( LPD ) and superoxide dismutase ( SOD ) in serum and synovia were observed in two groups . Results After treatment , the data of VAS score , Womac score , Lequesne index in two groups were significantly improved , and the abilities to inhibit IL-1β, TNF-α, MMP-3 , NO, iNOS and LPD in treatment group were better than the control group .The treatment group also displayed a better capability in increasing SOD compared with the control group. Conclusion Kanggu Zengsheng capsule has a better efficacy on knee -OA than traditional treatment methods ( diacereinand plus celecoxib ).
