Clinical effects of knee replacement postoperative reducing hemoglobin of tranexamic acid application
10.13699/j.cnki.1001-6821.2015.13.008
- VernacularTitle:氨甲环酸对膝关节置换术后血红蛋白降低的临床研究
- Author:
Fei XU
1
;
Yong-Ming LV
;
Ying-Chun SONG
;
Xia LI
;
En-Hong XING
;
Yang YANG
;
Yuan-Liang DU
;
Li-Chao ZHANG
;
Hai-Feng DAI
;
Xiao-Qiang DONG
;
Wen-Jing HE
;
Yan-Bo ZHANG
Author Information
1. 承德医学院 附属医院 骨外三科
- Keywords:
tranexamic acid;
dose;
knee arthroplasty;
hemoglobin
- From:
The Chinese Journal of Clinical Pharmacology
2015;(13):1246-1248
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of knee replacement postoperative on reducing hemoglobin by the different doses of tranexamic acid application.Methods A total of 116 knee replacement patients were enrolled and divided into the treatment group and the control group , 58 cases in each group .The surgical procedures and methods of the two groups were same , as patients in the control group were given intrave-nously before incision tranexamic acid 50 mg? kg -1 , and those in the treatment group received tranexamic acid 100 mg? kg -1 . During the peri-operative phase , the index of operation time , incision size , blood loss during operation , post -surgery drainage and the total number of blood transfusion , as well as hemoglobin were observed . Results Patients in two groups were all discharged after successful com-pletion surgery .The blood loss , postoperative drainage , the total amount of blood transfusion of the treatment group were significantly less than those of control group ( P<0.05 ) .The postoperative values in the two groups were showed significantly decreased ( P<0.05 ) , but preoperative hemoglobin values of the treatment group were significantly higher (P<0.05).The data of preoperative and postoperative coagulation indicators compared between two groups showed no significant difference .Patients were followed up for 3 months.The incidence of complications of deep vein thrombosis (1 case), acute myocardial infarction ( 0 case), transient neuro-logical symptom (1 case) in the treatment group were significantly lower than that in control group (5, 3, 4 cases) (P<0.05).Conclusion High dose of tranexamic acid applications can reduce blood loss and transfusion knee re -placement volume , and relieve the postoperative decrease of hemoglobin , meanwhile , it has no obvious effect on coagu-lation function with defined security .
