A Clinical Study on Malignant Germ Cell Tumor of Ovary.
- Author:
Yong Sik KIM
1
;
Myoung Sook JO
;
Cheol Hong KIM
;
Ki Min KIM
;
Moon Kyo JO
;
So Yi RIM
;
Da Rin KI
;
Jae Young LEE
;
Seok Mo KIM
;
Ho Sun CHOI
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Chonnam National University, Gwangju, Korea. seokmo2001@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Malignant germ cell tumor;
Tumor marker;
Chemotherapy
- MeSH:
Carcinoma, Embryonal;
Choriocarcinoma;
Drug Therapy;
Drug Therapy, Combination;
Dysgerminoma;
Endodermal Sinus Tumor;
Female;
Germ Cells*;
Humans;
Neoplasms, Germ Cell and Embryonal*;
Ovariectomy;
Ovary*;
Pregnancy;
Survival Rate;
Teratoma;
Biomarkers, Tumor
- From:Korean Journal of Obstetrics and Gynecology
2005;48(4):910-918
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: to evaluate the clinicopathologic characteristics of patients with ovarian malignant germ cell tumor. METHODS: We reviewed records of women who had malignant germ cell tumors of the ovary from 1991-2000. RESULTS: Thirty-seven women had surgical resections of malignant ovarian germ cell tumors and most received adjuvant therapy. Twenty-five women (68%) presented with stage I disease, and 12 (32%) had more advanced disease. Histology subtypes were: immature teratoma (n=16), dysgerminoma (n=9), yolk sac tumor (n=8), choriocarcinoma (n=2), embryonal carcinoma (n=1), and mixed germ cell tumor (n=1). The frequency of positive tumor markers were aFP, CA-125, beta-hCG, CA 19-9 and LDH in decreasing order. The mean age of the patients at presentation was 23.9 years (4-58). Surgical management of the 32 patients consisted of unilateral oophorectomy, or salpingo-oophorectomy, 1 woman with stage III disease underwent bilateral salpingo-oophorectomy and 4 women underwent total abdominal hysterctomy, bilateral or unilateral adnexectomy. Thirty-two women were treated with adjuvant combination chemotherapy (BEP, VAC, VBP) according to indications. The 5-year survival rate was 100%, and 5-year disease-free rate was 91.8%. Among twelve patients who attempted pregnancy, 8 succeeded in it and delivered normal full term babies. CONCLUSION: Current therapeutic strategies can allow most women with ovarian malignant germ cell tumors to have conservative surgery without compromising survival and to preserve their reproductive potential.
