Analgesic efficacy and safety of phloroglucinol in patients during coloscopy
10.13699/j.cnki.1001-6821.2015.12.013
- VernacularTitle:二氧化碳结合间苯三酚在结肠镜检查中的镇痛疗效与安全性评价
- Author:
Wen-Han SHI
1
;
Dao-Mei HU
;
Huan-Hai XU
;
Xu-Peng CHEN
;
Jian-Liang XIE
Author Information
1. 乐清市人民医院 消化内科
- Keywords:
coloscopy;
phloroglucinol;
pain;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(12):1118-1120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of phloroglucinol in patients during coloscopy.Methods A total of 164 patients who were prepared for coloscopy were randomized divided into experiment group ( n =88 ) and control group ( n =76 ) . All of the patients in the two groups were given food easy to digest 3 days before coloscopy and given polyethylene glycol electrolyte powder orally 12 and 6 hours before coloscopy.The carbom dioxide was used as the expansion of the gas, and patients in the experiment group were given phloro-glucinol 40 mg by intramuscular injection 10 minutes before the colosco-py, and those in the control group were given 0.9%NaCl 2 mL by intra-muscular injection.The data of visual analogue score( VAS) , rate of co-loscopy examination reached to the cecum, blood pressure and heart rate before and after the examination between the two groups were recorded. Results The VAS score were ( 4.1 ±1.4 ) and ( 6.3 ±1.5 ) points in the experiment and control group respectively, with experiment group significantly lower than the control group ( P<0.05 ) .The reach cecum rate was 90.9%in experiment group and 89.5%in control group, which indicated no statistical difference between the two groups ( P>0.05 ) .The blood pressure and heart rate of the two groups were not statistically different in the procedure of coloscopy (P>0.05).Conclusion Phloroglucinol can significantly decrease the VAS in the procedure of coloscopy, without increasing the incidence of adverse drug reactions.
