Clinical study of mianserin on post-stroke depression
10.13699/j.cnki.1001-6821.2015.12.002
- VernacularTitle:米安舍林治疗脑卒中后抑郁症的临床研究
- Author:
Ning TONG
1
;
Fei YU
;
Ling-Yun ZHU
;
Lin GU
;
Li MA
Author Information
1. 南京市第二医院药剂科
- Keywords:
mianserin;
stroke;
depression;
hamilton depression scale;
treatment emergent symptom scale
- From:
The Chinese Journal of Clinical Pharmacology
2015;(12):1082-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of mianserin on post-stroke depression.Methods A total of 100 patients were random-ly selected and divided into treatment group ( 50 patients ) and control group ( 50 patients ) according to simple random sampling.Patients in treatment group were treated with mianserin ( the initial dose was 15 mg? d-1 , and 1 week later the dose was added to 60 mg? d-1 ) and those in control group with amitriptyline ( the initial dose was 30 mg? d-1 , and 1 week later the dose was added to 150 mg? d-1 ) .The data of hamilton depression scale(HAMD), treatment emergent symptom scale(TESS) and activities of daily living(ADL) were assessed before treat-ment and 2, 4, 6 and 8 weeks after the treatment.Results The markedly effective rate in treatment group and control group were 86.0%and 78.0%, but the difference was not statistical different ( P >0.05 ) .The data of HAMD scores in two groups were both decreased compared with before treat-ment, but without statistical difference (P>0.05), the difference of TESS scores during the treatment were all significant in two groups (P<0.01). Conclusion Mianserin can relieve the anxiety of patients with post-stoke depression quickly and promote their function to be recovered effectively.
