Progress in search for relationship between Toll like receptor 4 with the pathogenesis of diabetic nephropathy
10.13699/j.cnki.1001-6821.2015.11.039
- VernacularTitle:Toll样受体4与糖尿病肾病的发病机制相关性的研究进展
- Author:
Wei-Wei CHANG
1
;
Lian-Ping HE
;
Ying-Shui YAO
Author Information
1. 皖南医学院 公共卫生学院
- Keywords:
diabetic nephropathy;
Toll like receptor 4;
inflammation
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):1066-1068
- CountryChina
- Language:Chinese
-
Abstract:
So far, the etiology and pathogenesis of diabetic nephropathy have not been clear.Recent studies indicated that inflammatory factors play important roles in the pathogenesis and development of diabetic nephropathy.While Toll like receptor 4 can activate the downstream sig-nal molecules through the myeloid differentiation factor 88 ( MyD88 ) depen-dent and the MyD88 independent pathway, so as to induce immune responses.This article makes a new survey on the pathogene-sis of diabetic nephropathy inflammation and its relationship with Toll like receptor 4.
