Surveillance of antimicrobial resistance in nonfermenting gram-negative bacteria in China of 2012
10.13699/j.cnki.1001-6821.2015.11.025
- VernacularTitle:2012年中国非发酵革兰阴性杆菌耐药监测
- Author:
Ling-Yun ZHANG
1
;
Yun LI
;
Peng-Yuan WANG
;
Yu-Cun LIU
Author Information
1. 北京大学 第一医院
- Keywords:
resistance surveillance;
nonfermenting gram-negative;
drug susceptibility
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):1001-1006
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antimicrobial resistance of nonfermenting gram-negative bacteria in China in 2012.Methods All the clinical isolates of nonfermenting gram -negative bacteria were collected from 557 tertiary hospitals from 1st January 2012 to 31st December 2012 in China.The antimicrobial susceptibilities of the isolates were de-termined by using various methods such as broth microdilution, disk diffusion, or E-test which according to CLSI 2012 guideline.The sus-ceptibility data were processed with WHONET 5.6 software.Results A total of 198334 nonfermenting gram-negative bacteria susceptibility data were obtained.Among all the isolates, the top 3 isolated nonfermenting gram-negative strains were Pseudomonas aeruginosa ( 80964 strains, 40.8%) , followed by Acinetobacter baumannii(67368 strains, 34.0%) , and Stenotrophomonas maltophilia ( 17520 strains, 8.8%).Against Pseudomonas aeruginosa, polymyxin B, tobramycin, ceftazidime, ciprofloxacin, levofloxacin, cefepime, gentamicin and cefoperazone/sulbactam ( CSL) were the only agents to which >70%of isolates were susceptible.No antibiotics except polymyxin B ( 96.9%) , minocycline ( 61.4%) , amikacin (58.7%), CSL (54.3%) and tobramycin (51.3%) were active more than 50% against Acinetobacter baumannii.Susceptibility rates of carbapenem against Acinetobacter baumannii were around 49%, about 9 percentage points higher than 2011 results.There are some differences among the monitoring results from various districts in China.The suscep-tibilities of Pseudomonas aeruginosa and Acinetobacter baumannii to the tested antimicrobial agents in Central China were generally low, whereas the antimicrobial susceptibilities of Acinetobacter baumannii from North China were genera-lly high.Conclusion The multidrug resistance of nonfermenting gram -negative bacteria, especially Acinetobacter baumannii, has become a worldwide problem.There are some differences among the susceptibilities of isolates from various districts.Polymyxin B has the most effective in vitro antimicrobial activity against Pseudomonas aeruginosa and Acinetobacter baumannii isolates, the emerging resistant isolates should cause enough attention.Further surveillance needed to be strengthened to prevent the further development and spread of resistant bacteria.
