Surveillance of antimicrobial resistance in Enterobacteriaceae isolated from first class hospitals in China of 2012
10.13699/j.cnki.1001-6821.2015.11.021
- VernacularTitle:2012年中国三级医院分离的肠杆菌科细菌耐药监测报告
- Author:
Yuan LV
1
;
Bo ZHENG
;
Lan-Qing CUI
;
Yun-Cun LIU
Author Information
1. 北京大学第一医院
- Keywords:
Enterobacteriaceae;
antimicrobial resistance surveillance;
minimum inhibitory concentration;
susceptibility;
resistance
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):976-983
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antimicrobial resistance of Enterobacteriaceae isolated from patients of first class hospitals in China in 2012.Methods All the clinical isolates of Enterobacteriaceae were collected and the susceptibility tests of the isolates were performed by 557 first class hospitals around China from 1st Jan.2012 to 31st Dec.2012.The susceptibilities of isolates to antimicrobial agents were determined by using CLSI (2010) guideline and the susceptibility data were processed with Whonet 5.6 software.Results A total of 372052 clinical isolates were collected.Among all the strains Escherichia coli ( 161211starins, 43.3%) outnumbered the other bacteria, followed by Klebsiella pneu-moniae (112600 strains, 30.3%), Enterobacter clacaer (31887strains, 8.6 %).The most effective antimicrobials were carbapenems.The re-sistant rates of Escherichia coli to imipenem and meropenem were both be-low 12.5%, and the rates in other Enterobacteriaceae were below 10%.Besides this, piperacillin/tazobactam, cefoperazone/sulbactam and ami-kacin demonstrated good antibacterial activity against Enterobacteriaceae in vitro.Overall, little difference was observed in the resistant rates of Enterobacteriaceae isolated from first class hospi-tals in different parts of China.Conclusion Enterobacteriaceae from firs class hospital were of different degree resis-tance to various antimicrobial agents.Carbapenems remained very high activity against Enterobacteriaceae,but the car-bapenem resistance strains has appeared and the issue should be attracted attention.
