Surveillance of antimicrobial resistance among clinical isolates from intensive care units in tertiary hospital, 2012
10.13699/j.cnki.1001-6821.2015.11.020
- VernacularTitle:2012年度全国三级医院重症监护病房来源细菌耐药分析
- Author:
Xiao-Jiang ZHANG
1
;
Bo ZHENG
;
Yuan LV
;
Ying-Chun XU
Author Information
1. 中国医学科学院 北京协和医院 检验科
- Keywords:
bacterial resistance;
intensive care unit;
antimicrobial susceptibility testing;
antimicrobial agent
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):970-975
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and antimicrobial resistance of clinical isolates derived from intensive care unit(ICU) pa-tients in China in 2012.Methods A total of 94178 non -duplicate clinical isolates from ICU of 557 tertiary hospitals were collected from January 2012 to December 2012.Antimicrobial susceptibility testing was carried out according to a unified using disc diffusion test ( Kirby-Bauer method ) or automated systems.The data were analyzed by WHONET 5.6 software according to Clinical and Laboratory Standards Institute ( CLSI) 2012 breakpoints.Results Among these 94178 non-duplicate clinical isolates, gram-negative organisms and gram-positive organisms accounted for 75.6% and 24.4%, respectively.The 5 most common pathogens in ICU were Acinetobacter baumannii ( 15.8%) , Klebsiella pneumoniae ( 14.7%) , Pseudomonas aeruginosa ( 12.8%) , Escherichia coli ( 12.5%) and Staphylococcus aureus (8.5%).Methicillin -resistant Staphylococcus aureus ( MRSA ) strains and coagulase -negative Staphylococcus ( MRCNS) accounted for 57.5% and 83.7%, respectively.However, 69.2% of Staphylococcus aureus strains were still susceptible to trimethoprim -sulfamethoxazole, while 83.9% of CNS strains were susceptible to rifampin.No Staphylococcus aureus strain was resistant to vancomycin, teicoplanin and linezolid.2.1% of the CNS strains were found resistant to teicoplanin.The resistant rates of Enterococcus faecalis and Enterococcus faecium to vancomycin, teicoplanin and linezolid were 1.8%, 3.1%,2.3% and 5.9%,5.9%1.4%, respectively.Extended spectrum β-lactamases ( ESBLs)-producing strains accounted for 67.5%, 45.4%, 32.5%and 39.5%in Escherichia coli, Kleb-siella pneumoniae, Klebsiella oxytoca and Proteus mirabilis, respectively.Overall, 2.2%-10.4%of the Enterobacteria-ceae strains were resistant to carbapenems.The resistance rates of Acinetobacter baumannii to imipenem and meropenem were 70.8 and 69.2%, respectively.The resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 38.5%and 37.4%, respectively.Conclusion Bacterial resistance is still an serious problem in ICU in China, espe-cially the carbapenem resistant Enterbacteriaceae and Acinetobacter baumannii.It is mandatory to take effective hospital infection contral measures and rational use antibiotics.
