Effect of the low molecular weight constituents in Angelica Sinensis polysaccharide to the ability of learning and memory in vascular dementia rats
10.13699/j.cnki.1001-6821.2015.11.016
- VernacularTitle:当归小分子多糖对血管性痴呆大鼠学习与记忆功能的影响
- Author:
Hui ZENG
1
;
Jie HU
Author Information
1. 武汉大学中南医院药剂科
- Keywords:
low molecular weight constituents in Angelica Sinensis poly-saccharide;
vascular dementia;
memory;
Tau protein
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):954-956
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of low molecular weight con-stituents in Angelica Sinensis polysaccharide ( ASP ) on the ability of learning and memory in vascular dementia ( VD ) rats.Methods The animals were devided into 6 groups: shame operation group, model group, control group, low, middle and high doses of low molecular weight constituents in ASP group.The VD model was established by in-jecting cruor embolus of the same kind rats into the internal carotid arter-y.Low, middle and high doses of low molecular weight constituents in ASP group were given low molecular weight constituents in ASP 0.08 , 0.15, 0.3 g· kg -1 , shame operation group and model group were given the same volume 0.9%sodium chloride, control group was given Xuesai-tong injection 42 mg· kg-1 ip qd for 28 days.The ability of learning and memory was estimated by Morris trial.The expression of Tau protein in the rat brain was determined.Results Low molecular weight constitu-ents in ASP can shorten escape latency, increase the original-platform staying time.And same time it can decrease the concentration of Tau protein in rat brain.Conclusion Low molecular weight constituents in ASP may protect the ability of learning and memory in VD rats.Maybe it is related to decrease the expression of Tau protein.
