Effect of Guben Kechuan Granules on expression of thymus index and spleen index of rats with experimental chronic obstructive pulmonary disease
10.13699/j.cnki.1001-6821.2015.11.011
- VernacularTitle:固本咳喘颗粒对实验性慢性阻塞性肺疾病大鼠胸腺指数及脾指数的影响
- Author:
Wen-Long WANG
1
;
Zi-Kai SUN
;
Li-Hua XU
;
Xuan-Xuan ZHU
Author Information
1. 杭州市中医院重症医学科
- Keywords:
chronic obstructive pulmonary disease;
thymus index;
spleen index;
Guben Kechuan Granules
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):935-937
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Guben Kechuan Gra-nules( GKG) on expression level of thymus index and spleen index of rats with chronic obstructive pulmonary disease ( COPD ).Methods Rats models with COPD made by fumigation and dripping lipopolysaccharide.The rats were randomly divided into 6 groups:normal group, model group, high,middle,low doses (2.28,1.14,0.57 g· mL-1) of GKG groups, and Guben Kechuan tablets group.From the third day of modeling, medicines were administered to rats by means of intragastric administration for consecutive 28 days.Two days after the finishing of in-tragastric administration,rats were executed and samples were collected. And then the spleen index and thymus index were calculated after the spleen and thymus were peeled from rats.Results Thymus index and spleen index expression level in GKG group increased obviously, with a significant difference compared with model group ( P <0.05 ) . Conclusion GKG can enhance immune function in the airway of rats with experimental COPD by regulating thymus index and spleen index expression level.
