Relationship between genetic polymorphisms of cytochrome P4502C8 and cytochrome P4502J2 with the risk of Alzheimer′s disease in Chinese Han population
10.13699/j.cnki.1001-6821.2015.11.008
- VernacularTitle:细胞色素P4502C8和细胞色素P4502J2基因多态性与中国汉族散发性阿尔茨海默病的相关性研究
- Author:
Bao-Xia HE
1
;
Hua-Cheng YAN
;
Mu-Kun HUANG
;
Wen-Zhou ZHANG
;
Xiu-Li ZHAO
Author Information
1. 郑州大学 附属肿瘤医院 河南省肿瘤医院药学部
- Keywords:
Alzheimer′s disease;
cytochrome P4502 C8;
cytochrome P4502 J2;
genetic polymorphism
- From:
The Chinese Journal of Clinical Pharmacology
2015;(11):924-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the association between cytochrome P450 2C8 ( CYP2C8 ) and CYP2C9 polymorphisms and the risk of Alzheimer′s disease ( AD ) in Chinese Han population.Methods A case-control study was carried out to compare the distribution of geno-types and genetic frequencies of CYP2C8 and CYP2C9 polymorphisms between Alzheimer′s disease ( n =206 ) and healthy volunteers ( n=256 ) .Genomic DNA was extracted from whole blood using DNA blood Kit.Matrix-assisted laser desorption ionization time-of -flight mass spectrometry ( MALDI-TOF-MS) .Matrix-assisted laser desorp-tion ionization time-of-flight mass spectrometry ( MALDI-TOF-MS) was used to identify the polymorphisms of CYP2C8 and CYP2J2. Results There were no significant differences of CYP2C8 and CYP2C9 genotypes between the cases and control groups.The haplotype C-T of CYP2C8 associated with the AD group( P<0.001,OR=2.57,95%CI:1.97 -3.35 ) .Conclusion The haplotype C -T of CYP2C8 ( rs1058932, rs2275622 ) increased the risk of Alzheimer′s disease in Chinese Han population.
