The effects of Raloxifene therapy on endometrium in postmenopausal women.
- Author:
Gwang Jun KIM
1
;
Hyoung Moo PARK
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University, Seoul, Korea. hmpark@hananet.net
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Raloxifene;
Endometrium;
Postmenopause
- MeSH:
Endometrium*;
Female;
Humans;
Postmenopause;
Raloxifene Hydrochloride*;
Selective Estrogen Receptor Modulators;
Ultrasonography
- From:Korean Journal of Obstetrics and Gynecology
2005;48(4):962-968
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine the effects of a selective estrogen receptor modulator (SERM), raloxifene, on endometrium in postmenopausal women. METHODS: Double-blind randomized controlled study was designed for 138 healthy postmenopausal women to determine the effects of raloxifene on postmeonopausal endometrium. The women were randomly assigned to receive either placebo, or raloxifene HCl 60 mg/day for 6 months. Transvaginal ultrasound was done at baseline and at 6 months later. RESULTS: Mean endometrial thickness of normal postmenopausal women was 3.4 ( +/- 1.6) mm. Mean endometrial thickness was decreased by 0.2 mm in both groups, but with no statistical significance. CONCLUSION: Raloxifene 60 mg/day did not stimulate the endometrium after 6 months of use in postmenopausal women.
