Research progress on antiatherosclerosis mechanism of liver X receptors
10.13699/j.cnki.1001-6821.2015.10.038
- VernacularTitle:肝X受体抗动脉粥样硬化作用机制研究进展
- Author:
Jing WEI
1
;
Jing-Rui CHEN
;
Lin MIAO
;
Guan-Wei FAN
Author Information
1. 天津中医药大学 中医药研究院 药理毒理部
- Keywords:
liver X receptor;
atherosclerosis;
lipid metabolism;
inflammation
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Liver X receptor is a ligand -activated transcription factor of nuclear receptor super family .It played a key role in the regulation of lipid metabolism.In the past decade , numerous studies show that liver X receptor are involved in a series of physiological processes such as meta-bolism and inflammation by activating or inhibiting its target genes that are so closely linked with cardiovascular diseases .In recent years, a large number of studies have shown that liver X receptor are increasingly prominent in fighting against atherosclerosis . In this paper , we will review the targets of the LXR pathways on the pathogenesis of atherosclerosis.
