Effects of the aqueous extracts of Eclipta Prostrata L.on plasma lipid levels and vascular intima in rats with hyperhomocysteinemia
10.13699/j.cnki.1001-6821.2015.10.034
- VernacularTitle:旱莲草水提取物对高同型半胱氨酸血症大鼠血脂及血管内膜的影响
- Author:
Chuan-Feng HUANG
1
;
Jiu-Gang QIN
;
Ai-Mei WANG
;
Rong-Zhi LIU
;
Yu-Hong MA
;
Qing-Chun LIU
;
Dong ZHANG
Author Information
1. 南阳医学高等专科学校 基础医学部
- Keywords:
Eclipta prostrata L;
hyperhomocysteinemia;
serum lipid;
vascular intima
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):882-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the aqueous extracts of Eclipta Prostrata L.( EPL) on plasma lipid levels and the structure of vascular intima in rats with hyperhomocysteinemia ( Hhcy ) . Methods High L -methionine diet was used to construct HHcy rat model.Fifty SD rats were randomly divided into five groups:normal group, model group, lovastatin group (2 mg? kg -1 ), Eclipta Prostrata L.(EPL) low-and high-doses groups (5, 10 g? kg -1 ).The drags were administrated by intragastric administration once a day . After 8 weeks administration , the level of serum homocysteine ( Hcy ) , total cholesterol (TC) and trigly-ceride ( TG) were detected by biochemical analysis.While nitric oxide (NO), endothelin (ET) and thromboxane B2 ( TXB2 ) were measured by enzyme linked immunosorbent assay (ELISA).The histopathological examination of the thoracic aortas were observed microscopically afterhematoxylin -eosin ( HE ) staining. Results Compared with model group , serum levels of Hcy , TG, TC, ET and TXB 2 were significantly decreased ( P<0.05 ) in EPL groups and lovastatin group , while NO levels were significantly increased ( P<0.05) in high dose EPL group.HE sections showed that the shape of thoracic aortas looks as normal .Conclusion The aqueous extract of EPL could effectively reduce serum Hcy and regulate plasma lipid levels , thus it could alleviate vascular damage .
