Effect of Shengmai Solvent on myocardial fibrosis and lipid metabolism in rat model of diabetic cardiomypathy
10.13699/j.cnki.1001-6821.2015.10.033
- VernacularTitle:生脉饮对糖尿病大鼠心肌病变及脂质代谢的作用研究
- Author:
Jia-Na SHI
1
;
Zuo-Wu YE
;
Chun-Fang LU
;
Dan-Yan ZHU
Author Information
1. 浙江省立同德医院药剂科
- Keywords:
diabetic cardiomypathy;
Shengmai Solvent;
myocardial fibrosis;
lipid metabolism
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):878-881
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Shengmai Solvent on myocardial fibrosis in rat model of diabetic cardiomypathy . Methods Wistar rats of 72 were randomly divided into 6 groups, including control group , model group , prevetion group , low -dose , mid-dose and high -doses of test groups. Shengmai Solvent was administered via gavage. Prevetion group ( Shengmai Solvent , 12 mL? kg -1 ) was administered at the beginning . Low -dose ( 3 mL? kg -1 ) , mid -dose ( 6 mL ? kg -1 ) and high -dose ( 12 mL? kg -1 ) groups were administered with Shengmai Solvent at 5th week. All groups except control group were fed on high -cholestrerol diet for 4 weeks with intraperitoneal injection of streptozotocin ( 35 mg? kg -1 ) . One week later , blood glucose is checked , and those with two consecu-tive blood glucose ≥16.7 mmol? L-1 .The blood glucose , lipid were detected at 15 th weeks after administration .The rats were sacrificed for determination of heart wet weight . Cardiac collagen was detected by RT-PCR.Results Compared with model group , the heart weight /body ratio were significantly decreased in the Shengmai groups .The level of HDL and ApoAI /ApoB were significantly increased in Shengmai groups.The level of LDL in prevetion group was decreased significantly .Conclusion These results indicate that the mechanism of Shengmai reduced the progression of DCM might be related to alteration of lipid metabolism .
