Anti-tumor effect of water extract from stem of Coix Lachryma-jobi L.in mice
10.13699/j.cnki.1001-6821.2015.10.027
- VernacularTitle:薏苡茎水提取物对 H22荷瘤小鼠的抗肿瘤作用研究
- Author:
Sheng-Qi GUO
1
;
Ting-Zhang HUANG
;
Yuan-Hui LI
;
Ying HUANG
;
Zhao-Die LI
;
Xi-Ning QIN
;
Xiao-Ying ZHU
;
Suo-Yi HUANG
Author Information
1. 右江民族医学院临床学院
- Keywords:
water extract from stem of Coix Lachryma -jobi L.;
liver cancer H22;
anti-tumor
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):855-857
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the tumor inhibitory effects and an in-fluence on immune organs of the water extract from stem of Coix Lachry-ma-jobi L.(WESCLL) in mice with liver cancer H22.Methods The experimental subjects were using mice with liver cancer H 22.The mice are randomly divided into 7 groups and were fed 0.9%sodium chloride , cyclophosphamide (0.02 g? kg -1 ), WESCLL(2,4,6,8,10 g? kg -1 ) by oral gavages.After 9 days′administration, the mice were killed. Their subcutaneous sarcoma ,liver,thymus and spleen were separated and weighted.Then the tumor inhibiting rates and liver , thymus and spleen index were calculated.Results The WESCLL has obvious effects on re-straining the liver cancer H22.There was significant difference compared with model group (P<0.05).The effect of WESCLL is more noticeable on liver index and weigh′s increase of the mice ( P<0.05 ) .There was not significant difference on thymus and spleen indexes compared with model group ( P<0.05 ) .Conclusion WESCLL have distinct effect on anti-tumor.
