Effect of Guben Kechuan granules on expression of pathology and T lymphocyte subsets in rats with chronic obstructive pulmonary disease
10.13699/j.cnki.1001-6821.2015.10.023
- VernacularTitle:固本咳喘颗粒对慢性阻塞性肺疾病大鼠病理及T 淋巴细胞亚群的影响
- Author:
Wen-Long WANG
1
;
Zi-Kai SUN
;
Li-Hua XU
;
Xuan-Xuan ZHU
Author Information
1. 杭州市中医院重症医学科
- Keywords:
chronic obstructive pulmonary disease;
lung tissue patholo-gy;
T lymphocyte subsets;
Guben Kechuan Granules
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):840-842
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Guben Kechuan Granules ( GKG) on expression level of T lymphocyte subsets in rats with chronic obstructive pulmonary disease ( COPD ) .Methods Rat models with COPD made by fumigation and dripping lipopolysaccharide . The rats were randomly divided into 6 groups:normal group, model group, high, middle,low doses (2.28,1.14,0.57 g? mL-1)GKG groups, and Guben Kechuan Tablets group .From the third day of modeling , medicines were administered to rats by means of intragastric administration for consecu-tive 28 days.Two days after the finishing of intragastric administration , rats were executed and samples were collected .T lymphocyte subsets ex-pression level in rat was tested by means of rapid immunohistochemistry method.Results T lymphocyte subsets expression level in low -dose groups of GKG decreased obviously , with a significant difference com-pared with model group ( P<0.05 ) .Conclusion GKG can enhance immune function in the airway in rats with experimental COPD by regula-ting T lymphocyte subsets expression level .
