Temporal expression profile of HSP70 in serum of patients with spinal cord injury and its clinical significance

VernacularTitle:热休克蛋白70在脊髓损伤患者血清中的表达及临床意义
Author: Si-Yan GUAN ¹ ; Yong-Liang HU ; Bin YU ; Guo-Qing WANG ; Xiao-Fan WANG ; Sen CHEN
Author Information

1. 衢州市柯城区人民医院骨科
Keywords: spinal cord injury; heat shock protein 70 ( HSP70 )
From: The Chinese Journal of Clinical Pharmacology 2015;(10):830-832
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of serum heat shock protein 70 ( HSP70 ) in patients with spinal cord injury and its correlation with the extent of injury severity .Methods There were 76 patients with spinal cord injury in experiment group , and 30 healthy volunteers enrolled in control group.Blood samples were obtained at 6, 12, 24, 72 , 120 h after spinal cord injury in 76 patients.Western blot analysis was used to determine the expression of HSP 70 and the correlation between HSP70 level and the extent of injury severity was also evaluated . Results The patients with spinal cord injury showed a higher expression of HSP70 than control group at 6 h, and peaked at 12 h.But the expression decreased 72 , 120 h post spinal cord injury ( P<0.05 ) . Furthermore , the level of HSP70 was positively correlated with the extent of injury severity in spinal cord injury patients ( P <0.05 ) . Conclusion Increased serum HSP70 level may constitute an early predictor of unfavorable outcome in spinal cord injury patients .