Effect of Xianlinggubao capsule in the treatment of postmenopausal osteoporosis and its effect on osteoprotegerin, receptor activator of nuclear factor-κB ligand
10.13699/j.cnki.1001-6821.2015.10.019
- VernacularTitle:仙灵骨葆胶囊治疗绝经后骨质疏松的疗效及其机制研究
- Author:
Xin CHEN
1
;
Xiong-Bai ZHU
;
Wen-Jun LIN
;
Lu WANG
;
Sheng-Wu YANG
Author Information
1. 温州医科大学 附属第一医院 骨科
- Keywords:
Xianlinggubao capsule;
postmenopausal osteoporosis;
osteoprotegerin;
receptor activator of nuclear factor-κB ligand
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):827-829,854
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effect of Xianlinggubao capsule in the treatment of postmenopausal osteoporosis ( PMOP) and its effect on osteoprotegerin , receptor activator of nuclear factor -κB ligand ( RANKL) in serum.Methods The patients in control group was trea-ted with calcium 600 mg? d-1 and vitamin D 0.25 μg? d-1 orally.The patients in trial group was added Xianlinggubao capsule 1.5 g bid orally on the base of treatment in control group .Treatment lasted for 6 months. After the treatment , the clinical efficacy was observed .The bone mineral density ( BMD ) was detected and the level of osteoprotegerin′s and RANKL′s were determined.Results The clinical total effective rate of trial group ( 93.30%) was significantly better than control group (70.00%,P<0.05).BMD of trial group(0.97 ±0.10, 0.79 ±0.10) was improved better than control group ( 0.77 ±0.10 , 0.62 ±0.10 ) , the difference was statistically significant ( P <0.05 ) .The expression level of osteoprotegerin in trial group was significantly higher than control group (142.24 ±6.54 vs 119.18 ±5.71 ).And the expression level of RANKL was significantly lower than control group ( 6.62 ±1.04 vs 8.46 ±1.63 ) , the difference was statistically significant ( P <0.05 ) . Conclusion There was a good clinical effect to treat PMOP with Xianlinggubao capsule , and its mechanism may be related to upregulate the expression of osteoprotegerin , downregulate the expression of RANKL.
