Paroxetine combined with amisulpride in the treatment of somatoform disorders
10.13699/j.cnki.1001-6821.2015.10.016
- VernacularTitle:帕罗西汀联合氨磺必利治疗躯体形式障碍的临床研究
- Author:
Yi-Ping TANG
1
;
Wen-Yao QI
;
Qian-Qian CHEN
;
Min-Min CAO
;
Zhi-Jie CAI
Author Information
1. 台州市第二人民医院 心身科
- Keywords:
somatoform disorder;
amisulpride;
paroxetine;
clinical effect;
adverse drug reaction
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):818-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical efficacy and safety of paroxetine combined with low dosage of amisulpride on the treatment of somatoform disorders. Methods A total of 67 somatoform disorders patients were randomly divided into treatment group ( n=33 ) and control group( n =34 ) .Patients in the treatment group were given paroxetine combined with amisulpride treatment , paroxetine 20 mg? d-1 initially and adjusted to 20 -60 mg? d-1 within 1 week; amisulpride 50 mg? d-1 initially and adjusted to 100 -150 mg? d-1 within 1 week. And patients in the control group were given paroxetine as the same schedule of treatment group combined with placebo .The HAMD, HAMA and SCL-90 score were used to evaluate the symptoms before and at the time of 2, 4 and 6 weeks after treatment .Results The HAMD, HAMA and SCL -90 score were ( 19.52 ±2.98 ) , ( 22.64 ±3.42 ) and (3.01 ±0.72) in treatment group and (20.38 ±3.25),(21.87 ±3.31) and ( 2.82 ±0.68 ) in control group without statistical difference (P>0.05).After6weekstreatment,thescorewere(8.36±2.67),(9.38±2.23),(1.20±0.52)intreatment group and (11.33 ±3.02), (11.62 ±2.66), (1.67 ±0.59) in control group with statistical difference (P<0.05). The HAMD score was significantly decreased in the treatment group compared with control group 2 weeks after treatment ( P<0.05 ) .The HAMA and SCL-90 score in treatment group showed significant differences after 4 weeks treatment and especially 6 weeks later compared with control group (P<0.05).The total incidence of adverse drug reactions was 33.33% in the treatment group and 26.47% in the control group with no difference ( P >0.05 ) . Conclusion Paroxetine combined with low dosage of amisulpride can improve the symptom quickly for the treatment of somatoform disorders , without increasing adverse reactions .
