Clinical efficacy and safety of escitalopram oxalate versus paroxetine in the treatment of unipolar depression
10.13699/j.cnki.1001-6821.2015.10.014
- VernacularTitle:艾司西酞普兰与帕罗西汀治疗单项抑郁症的临床疗效及安全性研究
- Author:
Xiao-Su JIN
1
;
Xue-Ming XU
;
De-He XU
;
Ying-Ying CHEN
Author Information
1. 台州市第二人民医院药剂科
- Keywords:
escitalopram oxalate;
paroxetine;
unipolar depression;
efficacy;
toxicity
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effects and toxicity of escitalopram oxalate versus paroxetine in the treatment of unipolar depre-ssion.Methods 71patientswithconfirmeddiagnosisofunipolardepre-ssion ( UD ) were recruited and randomized divided in to escitalopram oxalate ( EO ) group with escitalopram oxalate 10 mg? d-1 ( max 20 mg? d-1 ) orally, and paroxetine ( PA ) group with paroxetine 20 mg? d-1 ( max 50 mg? d -1 ) orally, with 12 weeks treatment.At the time point of 2 , 4 , 8 and 12 -week the hamilton depression scale (HAMD), self-rating depression scale (SDS) and treatment emergent symptom scale ( TESS ) score were recorded and compared between the two groups. Results The HAMD and SDS score were significant decreased ( P<0.05 ) after 4 weeks treatment in the EO group , and sig-nificant decreased ( P<0.05 ) after 2 week in the PA group.The clinical efficacy was 72.97%and 70.27% according to HAMD and SDS in the EO group.The clinical efficacy was 70.59% and 67.65% according to HAMD and SDS in the PA group .No statistical difference was found between the two groups for the clinical efficacy (P>0.05).There was no significant difference between two group on incidence of adverse drug reaction ( P>0.05 ).Conclusion There was no significant difference for escitalopram oxalate and paroxetine in the treatment of unipolar depression , but paroxetine work quickly than escitalopram oxalate .
