Effects of Tongxinluo capsule on the signs of blood stasis and angiogenesis in the chronic total occlusion of coronary heart disease
10.13699/j.cnki.1001-6821.2015.10.008
- VernacularTitle:通心络胶囊对冠状动脉慢性完全闭塞病变患者血瘀征象及血管新生的影响
- Author:
Fang ZHANG
1
;
Kai-Han REN
;
Yu-Lin CHEN
;
Xing-Wei ZHANG
Author Information
1. 杭州师范大学 附属医院 心血管内科
- Keywords:
coronary heart disease;
chronic total occlusion;
blood stasis;
vascular endothelial growth factor;
basic fibroblast growth factor;
Tongxinluo capsule
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):793-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Tongxinluo capsule on the signs of blood stasis and angiogenesis in the chronic total occlusion of coronary heart disease .Methods Sixty-seven patients of chronic total occlusion of coronary heart disease ( which did not undergo percutaneous coronary intervention or coronary artery bypass grafting ) were randomly divided into treatment group ( 37 cases ) and control group ( 30 cases ) . In the control group , the conventional western medicine was applied ( That is legitimately given conventional antiplatelet , statin, βreceptor blocking agents , angiotensin converting enzyme inhibitors , calcium chan-nel blockers and nitrates treatment ).In the treatment group , on the basis of control group , the Tongxinluo capsules 3 pills were taken orally , 3 times per day for 3 months.Before and after 3 months treatment , the signs of blood stasis were observed and the levels of vascular endothelial growth factor ( VEGF) and basic fibroblast growth factor ( bFGF) were determined in two groups. Results The signs of blood stasis were relieved in either group after treatment .The blood stasis standard score in the treatment group was significantly lower than the control group ( P<0.05 ) .After treatment , the level of VEGF and bFGF in both groups were obviously higher than before ( P<0.05 ); the treatment group has a higher level of VEGF and bFGF ( P<0.05 ) compared with the control group .Conclusion Tongxinluo capsule can relieves the signs of blood stasis and elevate the levels of serum VEGF and bFGF of the chronic total occlusion of coronary heart disease .
