Almagate combined with lansoprazole in the treatment of stress ulcer patients with heavy craniocerebral injury
10.13699/j.cnki.1001-6821.2015.10.003
- VernacularTitle:铝镁加联合兰索拉唑治疗重型颅脑损伤应激性溃疡的临床研究
- Author:
Long-Ying MA
1
;
Ruo-Yang LIU
;
Ming-Dong WU
Author Information
1. 舟山市普陀医院药剂科
- Keywords:
almagate;
lansoprazole;
heavy craniocerebral injury;
stress ulcer;
efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2015;(10):777-779
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of almagate combined with lansoprazole in the treatment of stress ulcer patients with heavy craniocerebral injury .Methods A total of 60 stress ulcer patients with heavy craniocerebral injury were included in this study and were divided into experiment group ( n=28 ) and control group ( n=32).Patients in two groups all received regular treatment and nutrition such as dehydration and hormone to maintain electrolyte and acid -base balance.The patients in control group were treated with lansoprazole 30 mg+0.9%NaCl 100 mL by intravenous drip.Patients in the experiment group were given lansoprazole and almagate 1.5 mL by nasal feeding , tid.The course of the two groups were 7 days.The data of total efficacy , gastric acid pH and adverse drug reactions were compared between the two groups.Results The total efficacy were 82.1%and 71.8%in the experiment and control group , respectively , which showed no statistical difference ( P >0.05 ) . The pH of gastric acid after treatment was significantly higer than that before treatment ( P <0.05 ) .The pH of gastric acid was significantly different 6 hours after treatment between the two groups ( P<0.05 ) .No obvious adverse drug reaction was observed in the two groups in the period of treatment .Conclusion Almagate combined with lansoprazole is effective and safe in the treatment of stress ulcer patients with heavy craniocerebral injury.
