Effects of rosuvastatin preconditioning on the expression of interleukin -1βand interleukin-12 in rats with focal cerebral ischemia-reperfusion in rats
10.13699/j.cnki.1001-6821.2015.09.020
- VernacularTitle:瑞舒伐他汀对脑缺血再灌注后白细胞介素－1β和白细胞介素－12的影响
- Author:
Guo-Qian LI
1
;
Shu-Zeng CHEN
;
Jie-Hua WANG
;
Xiu-Xiu XU
;
Wen-Dong LIN
;
Yong-Hua XIE
Author Information
1. 福建医科大学 附属泉州第一医院 神经内科
- Keywords:
rosuvastatin;
cerebral ischemia -reperfusion;
interleukin -1β;
interleukin -12
- From:
The Chinese Journal of Clinical Pharmacology
2015;(9):744-746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of rosuvastatin on the expression of interleukin-1β( IL -1β) and interleukin -12 ( IL-12 ) in rats with focal cerebral ischemia-reperfusion.Methods Sprague-Dawley rats were randomly assigned into three groups: Sham operation group, focal cerebral ischemia-reperfusion group(model group) and rosu-vastatin preconditioning group ( test group) .Before making a model, the rats in the test group were lavaged with rosuvastatin 5 mg· kg-1 · d-1 , once a day for consecutive days.The middle cerebral artery occlusion reperfu-sion model was made by the suture method ( ischemia for 1 hour, and reperfusion for 12 hours).The level of IL-1βand IL-12 expression were measured by enzyme -linked immunosorbent assay ( ELISA ) and polymerase chain reaction ( PCR ).Results Compared with model group, the expression of IL-1βand IL-12 in the rats of test group were downregulated ( P<0.05 ).Conclusion Rosuvastatin can relieve the brain damage induced by focal cerebral ischemia -reperfusion, whose mechanisms seemed related to inhibiting the expression of IL-1βand IL-12.
