Influence of parecoxib Na on anesthesia recovery period of patients under the fast track anesthesia with remifentanil
10.13699/j.cnki.1001-6821.2015.09.009
- VernacularTitle:帕瑞昔布钠对瑞芬太尼快通道麻醉患者术后苏醒期影响的效果分析
- Author:
Xiao-Dao ZHOU
1
;
Hong-Jun GONG
;
Chi-Bo MA
Author Information
1. 宁波市鄞州二院 麻醉科
- Keywords:
parecoxib Na;
remifentanil;
anesthesia recovery period;
anesthesia;
clinical research
- From:
The Chinese Journal of Clinical Pharmacology
2015;(9):708-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of preoperative use of parecoxib Na during anesthesia recovery period on the fast track anesthe-sia with remifentanil.Methods A total of 105 cases who received lapa-roscopic cholecystectomy were randomly divided into three groups with 35 cases in each group.Patients in group A received parecoxib Na 40 mg dissolved in normal saline 10 mL through injection 20 min before induc-tion of anesthesia.Patients in group B received parecoxib Na 40 mg dis-solved in normal saline10 mL through injection 20 min before the end of surgery.Patients in group C received normal saline 10 mL through injec-tion 20 min before induction of anesthesia.The data of mean arterial pressure(MAP), heart rate (HR) and oxygen saturation (SPO2), ver-bal rating scale ( VRS) , sedation-agitation scale ( SAS) , ramsay sada-tion scale ( RSS ) and comfort score ( BCS ) were compared among three groups.Results The data of MAP, SAS and HR in group A and group B were significantly lower than those in group C, and the data of MAP, SAS and HR in group A were significantly lower than those in group B ( P<0.05).The data of RSS in group A was significantly lower than that in group B and RSS in group A and group B significantly higher than those in group C from T2 to T4 (P<0.05).The data of VRS in group A and group B were significantly lower than those in group C, and that in group A was signifi-cantly lower than group B each time point( P<0.05).Postoperative BCS in group A and group B were significantly higher than those in group C, and that in group A was significantly higher than group B( P<0.05).Conclusion Pre-operative use of parecoxib Na can significantly reduce the acute pain of the fast track anesthesia with remifentanil, effectively inhibiting hyperalgesia and reducing the patient's agitation.
