Efficacy and safety of rivaroxaban versus enoxaparin in prevention of deep vein thrombosis after major orthopedic surgery
10.13699/j.cnki.1001-6821.2015.09.004
- VernacularTitle:利伐沙班对比依诺肝素预防骨科大手术后深静脉血栓形成的疗效与安全性评价
- Author:
Hui-Jie LU
1
;
Ru-Jie ZHUANG
;
Zhi-Qing CHEN
Author Information
1. 杭州师范大学 附属医院 骨科
- Keywords:
rivaroxaban;
enoxaparin;
major orthopedic surgery;
deep vein thrombosis;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2015;(9):693-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of rivaroxaban versus enoxaparin in prevention of deep vein thrombosis after major orthopedic surgery.Methods A total of 212 patients who accepted major orthopedic surgery and received rivaroxaban or enoxaparin in prevention of deep vein thrombosis were recruited in this study.Of the included 212 subjects, 102 patients( experiment group) received rivaro-xaban 10 mg· d-1 orally 6 h after surgery for 28 days and 110 patients ( control group ) received enoxaparin 0.4 mL 12 h before surgery and after surgery for 10 days.The risk of developing deep vein thrombosis within 6 months, perioperative blood transfusion, secondary bleeding and hematoma were compared between the two groups.Results In the period of 6 moths follow-up, 3 (2.9%) and 2 cases (1.8%) of deep vein thrombosis were found in the experiment and control group, respec-tively, but without statistical difference ( P>0.05 ).And no significant difference in coagulation index were recorded between the two groups ( P>0.05).There were 8 cases of blood transfusion, 3 cases of seconda-ry bleeding, 2 cases of wound bleeding, 4 cases of hematoma and 1 case of wound infection in experiment group.And 11 cases of blood transfusion, 5 cases of secondary bleeding, 3 cases of wound bleeding, 5 cases of hematoma and 1 case of wound infection in control group were found.The risk of developing anticoagulation between the two groups was not statistically different ( P>0.05 ).Conclusion Rivaroxaban and enoxaparin in prevention of deep vein thrombosis after major orthopedic surgery has similar clinical efficacy and safety.
