Effects of sitagliptin combined with premixed insulin on blood glucose fluctuations in patients with type 2 diabetes
10.13699/j.cnki.1001-6821.2015.09.003
- VernacularTitle:西格列汀联合预混胰岛素对2型糖尿病患者血糖波动的影响
- Author:
Fen-Juan XU
1
;
Shao-Ping XUAN
;
Qing-Sen ZHANG
;
Chun-Hui ZHONG
;
Zhong-Qiu SHEN
;
Fei-Xia SHEN
Author Information
1. 桐乡市第一人民医院 内分泌科
- Keywords:
sitagliptin;
premixed insulin;
type 2 diabetes;
glucose fluctuation
- From:
The Chinese Journal of Clinical Pharmacology
2015;(9):689-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of sitagliptin combined with premixed insulin on blood glucose fluctuations in patients with type 2 diabetes.Methods A total of 42 patients with type 2 diabetes from April 2012 to November 2013 were randomly divided into two groups, treated with insulin aspart 30 injections alone 2 to 3 times a day( control group, n=21 ) or combined with oral sitagliptin once a day ( treatment group, n=21).The glucose fluctuations by fingertip blood glucose and continuous glucose monitoring ( CGM) were assessed and the changes of glucose fluctuations in two groups before and after treatment were com-pared as well as the incidence of adverse reactions.Results Compared with before treatment, the data of blood glucose fluctuations index in two groups were significantly decreased after treatment.The fingertip blood glucose results showed that standard deviation of blood glucose( SDBG) , coefficient of varicotion( CV) and postprandial blood glucose index were lower in treatment group after treatment(P<0.05).The date from CGM showed SDBG [(1.77 ±0.53) vs ( 2.39 ±0.80 ) mmol · L-1 ], was significantly lower in treatment group than that in control group( P<0.05).MAGE and MODD in treatment group was decreased than control group [ MAGE ( 4.36 ±1.14 ) vs ( 5.82 ±2.44 ) mmol · L-1 and MODD ( 1.32 ±0.37 ) vs (1.71 ±0.65)mmol· L-1], but there was no statistical difference found(P >0.05).Hypoglycemia time ratio in treatment group was lower than that in control group [ ( 0.86 ±1.58 )% vs ( 2.95 ±2.39 )%, P <0.05 ].Conclusion Sitagliptin combined with premixed insulin is more safe and convenient for reducing blood glucose level and glucose fluctuations.
