Role of p38 MAPK signal pathway in edaravone influencing cytokine on patients undergoing one lung ventilation
10.13699/j.cnki.1001-6821.2015.09.001
- VernacularTitle:p38 MAPK 信号通路在依达拉奉影响单肺通气患者炎症因子中的作用
- Author:
Xun-Jun SHUAI
1
;
Zhan-Qiu YAN
;
Hui LI
;
Deng-Bin AI
;
Hong-Xian CUI
Author Information
1. 青岛市市立医院 麻醉科
- Keywords:
p38 mitogen activated protein kinase;
edaravone;
interleukin-6;
interleukin-10
- From:
The Chinese Journal of Clinical Pharmacology
2015;(9):683-685,698
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of p38 mitogen-activated protein kinase( p38 MAPK) in edaravone influencing cytokine IL-6 and IL-10 on patients undergoing one lung ventilation.Methods Forty patients with lung cancer undergoing elective lung resection were randomly divided into control group ( n =20 ) and treatment group ( n =20 ).Anesthesia was induced with midazolam 0.03 mg · kg-1 , fentanyl 3 μg· kg -1 and 8% sevoflurane.Patients in edaravone group received edaravone 0.5 mg · kg-1 after induction of anesthesia, while those in control group were given 0.9%NaCl of the same volume.Blood sample were taken and detected before skin incision ( T0 ) , 60 min after lungs inflated( T1 ) and 1 h after surgery ( T2 ) for expression of phosphorylated p38 MAPK ( p -p38 MAPK ) , p38 MAPK and plasma concentration of interleukin-6(IL-6).The ratio between p-p38 MAPK and p38 MAPK was calculated.Results Compared with T0 , the data of p38 MAPK, p-p38 MAPK, p-p38 MAPK /p38 MAPK ratio and IL-6 concentration, IL-6/IL-10 ratio were all significantly increased at T1and T2(P<0.05).And those in treatment group were signifi-cantly lowered than those in control group at T1 and T2 ( P<0.05).Conclusion p38 MAPK signal pathway is involved in edaravone inhibiting proinflammatory cytokine and maintaining a relative stability of proinflammatory/anti -inflammatory cytokine in patients undergoing one lung ventilation.
