Research status of resistant mechanism of the carbapenems-resistant Pseudomonas aeruginosa
10.13699/j.cnki.1001-6821.2015.08.026
- VernacularTitle:耐碳青霉烯类铜绿假单胞菌耐药机制的研究现状
- Author:
Xiu-Zhen DI
1
;
Rui WANG
Author Information
1. 解放军总医院 转化医学中心 药物临床研究中心
- Keywords:
Pseudomonas aeruginosa;
carbapenem;
resistant mechanism
- From:
The Chinese Journal of Clinical Pharmacology
2015;(8):669-672
- CountryChina
- Language:Chinese
-
Abstract:
The outbreaks and the increased prevalence of carbapenem -resistant Pseudomonas aeruginosa have been continuously reported in hos-pitals worldwide , along with the increasing usage of Carbapenems .The infection caused by CRPA poses a serious public health threat . The mainly mechanisms of Pseudomonas aeruginosa resistant to carbapenems are the decreasing expression of outer membrane protein ( the mutation or loss of OprD 2 ) , the over-expression of efflux pump system , and the ca-pability of metallo-β-lactamases to hydrolyze most carbapenems , and so on.The effective antibiotics against carbapenem -resistant Pseudo-monas aeruginosa are limited.The insights into mechanisms of Pseudo-monas aeruginosa resistant to carbapenems may contribute to the develop-ment of new drugs and rational application of antibiotics in clinic .
